Throughout its history, Annamalai University has produced a myriad of exceptional individuals who have left an indelible mark in various fields. Some of the most notable alumni include:
- Dr. M. Karunanidhi: Former Chief Minister of Tamil Nadu and a prominent politician.
- Dr. D. S. Kothari: Renowned physicist and former Chairman of the University Grants Commission.
- Vairamuthu: Acclaimed poet and lyricist in the Tamil film industry.
- Dr. C. N. Annadurai: Influential politician and founder of the Dravida Munnetra Kazhagam party.
